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Low Levels of 'Memory Protein' Appear to Play Key Role in Cognitive Decline in Alzheimer's Disease

29.04.17 | Cuca Margoux

Researchers from Johns Hopkins Medicine and their collaborators say thatlow levels of a specific protein in the brains of people with Alzheimer's disease may contribute to changes in the pattern of neural activity that ultimately lead to the learning and memory loss that are hallmarks of the disease.

The Hopkins scientists—together with colleagues at the National Institutes of Health, the University of California San Diego Shiley-Marcos Alzheimer's Disease Research Center, Columbia University, and the Institute for Basic Research in Staten Island—studied human brain tissue samples and genetically engineered mice. They say their discovery could one day help experts develop new and better therapies for Alzheimer's and other forms of cognitive decline.